BME417HW2 - BME 417 HW2 1. My selected five recent journal...

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1 BME 417 HW2 1. My selected five recent journal articles on ion channels by Roderick MacKinnon is as follow: MacKinnon, R. et al. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415 , 287-94 (2002) Gouaux, E., MacKinnon, R. Principles of selective ion transport in channels and pumps. Science 310 , 1461-5 (2005) MacKinnon, R. et al. Gating the selectivity filter in ClC chloride channels. Science 300 , 108-12 (2003) Lee, S., MacKinnon, R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430 , 232-5 (2004) MacKinnon, R. et al. The principle of gating charge movement in a voltage-dependent K+ channel. Nature 423 , 42-8 (2003) 2. My favorite article: Principles of Selective Ion Transport in Channels and Pumps Eric Gouaux and Roderick MacKinnon With the recent discoveries of many channel protein structures through X-ray crystallography techniques, we are beginning to understand evolution’s answer to the challenges of maintaining life. The biochemical principles that allow these transporter proteins to perform their function are illustrated through a structural comparison of Glt Ph , K + Channel, ClC, and Ca2+ATPase. The mechanism of selectivity of Na + , K + , Ca 2+ , and Cl - transporters are also compared. Ion transport across membranes is a function essential to life. E.g., ion pumps build electrochemical gradient across membrane, which can be used for co-transport of many nutrients; ion channels allow selected ions to pass tahe membrane, which is the basis for neural signal transmission. Other important processes involving ion transport
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2 include ATP synthesis, cell volume regulation, and secretion of electrolytes across epithelium. There are two major classes of ion transporters – ion pumps and ion channels. Their requirements are very different: ion pumps have to transport a specific ion against it’s concentration gradient (through coupling with ATP hydrolysis or a downhill transport of another ion), while ion channels only have to transport a specific ion down it’s concentration gradient (usually at a very high conduction rate). These requirements, as
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BME417HW2 - BME 417 HW2 1. My selected five recent journal...

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