Transmissable Spongioform Encephalopathy

Transmissable - In Humans • Consuming contaminated meat products • Affects neurological tissue – NO BLOOD TRANSMISSION Scrapie • Can be

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A group of diseases caused by a Prion Only zoonotic TSE = BSE Humans TSE’s = Kuru Animal TSE’s BSE - cattle Scrapie - sheep + goats Chronic Wasting Disease - deer + elk ** Abnormal protein – extremely resistant - heat - normal sterilization processes - many disinfectants History:  KURU New Guinea in early 1900s People practicing cannibalism o Consuming parts of their loved ones after they died History:  SCRAPIE 250 years old, first U.S. case in 1947 BSE may have originated from scrapie 1993 peak of BSE in UK – thousands of cases reported weekly History:  CHRONIC WASTING DISEASE Seen in Colorado and Wyoming Deer and elk Not known to be zoonotic TRANSMISSION TRANSMISSIBLE SPONGIOFORM ENCEPHALOPATHY
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Unformatted text preview: In Humans: • Consuming contaminated meat products • Affects neurological tissue – NO BLOOD TRANSMISSION Scrapie: • Can be spread through placenta (ewe to lamb) • Young lambs often affected No vaccines or treatment available for all TSE’s Incubation periods: • Scrapie = 3.5 years • BSE = 2-8 years • CWD = 3-18 months Symptoms of Scrapie :- itching, loss of fleece- nervous + aggressive animals- sensitive to noise- lack of coordination- paralysis, tremors- wasting despite good appetite ** Scrapie is the “mad cow” of cattle Diagnosis : • Post-mortem o Microscopic examination of brain tissue at necropsy...
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This note was uploaded on 04/30/2008 for the course AVS 332 taught by Professor Launer during the Spring '08 term at Rhode Island.

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Transmissable - In Humans • Consuming contaminated meat products • Affects neurological tissue – NO BLOOD TRANSMISSION Scrapie • Can be

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