BCH Exm 3, Glycol

BCH Exm 3, Glycol - Glycolysis A 2 stage, 10 step process:...

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Glycolysis A 2 stage, 10 step process: Stage 1: C 6 sugar is cleaved into two C 3 sugars. Stage 2: Deals with the two C 3 sugars. Why run a 2 stage 10 step process?
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Glucose + P i G-6- P ATP + H 2 O ADP + P i Δ G o ʼ = +13.8 kJmol -1 Δ G o ʼ = -30.5 kJmol -1 Glucose + ATP G-6-P + ADP + H2O Δ G o ʼ = -30.5 +13.8 = -16.7 kJmol -1 Reactions are sometimes coupled to make them energetically favorable. This reaction is endergonic. This reaction is highly exergonic. Δ G o ʼ > 0 Δ G o ʼ < 0 Δ G o ʼ = Gibbs Free Energy at standard-state conditions of 1 M reactants and products at pH =7.
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Step #1 Glucose to Glucose-6-phosphate [G-6- Converting glucose to glucose-6-phosphate is an endergonic reaction but it can pulled along by coupling it to the hydrolysis of ATP. Energetics of Glycolysis Glucose + P i G-6- P Δ G o ʼ = +13.8 kJmol -1 This reaction is endergonic. ATP + H 2 O ADP + P i Δ G o ʼ = -30.5 kJmol -1 This reaction is exergonic. Combining both reactions . Δ G o ʼ = Δ G 2 o ʼ + Δ G 1 o ʼ = -16.7 kj/mole Δ G o ʼ > 0 Δ G o ʼ < 0 Because this step is highly exergonic, it is irreversible making it a key regulatory step in glycolysis.
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Step #2: Converts an aldose to a ketose Δ G o ʼ = +1.67
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This note was uploaded on 04/30/2008 for the course BIO 311 taught by Professor Martin,howlett during the Spring '08 term at Rhode Island.

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BCH Exm 3, Glycol - Glycolysis A 2 stage, 10 step process:...

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