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Unformatted text preview: 1 LJ The Citric Acid Cycle Chapter 19 in Campbell 2 LJ Overview of citric acid cycle • Other names: Krebs cycle (for Hans Krebs) or TCA (tricarboxylic acid) cycle. • In Eukaryotes, occurs in the mitochondria, whereas glycolysis occurs in the cytosol. .C Occurs under aerobic conditions. • Amphibolic: plays a role in both catabolism and anabolism. This is because some of the intermediate molecules are starting points for biosynthetic pathways. 3 LJ Overview of citric acid cycle, conI. • Receives input from glycolysis, as well as amino acids and fatty acids derived from hydrolysis of proteins and fats. • These can enter the cycle as acetyl-coA or as cycle intermediates. • First step: acetyl-coA combines with oxaloacetate, making a 6-carbon compound: citric acid. 4 LJ Location of the citric acid cycle in the mitochondria • The mitochondria have two membranes, the inner and outer. • Within the inner membrane is the mitochondrial matrix. • It is in the matrix that the citric acid cycle occurs, with one exception:- The enzyme that catalyzes the FAD-linked...
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