L20_2008_TOUCH&PRINCIPLES

L20_2008_TOUCH&PRINCIPLES - Sensory Neurobiology...

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1 1 Sensory Neurobiology Carl D. Hopkins [email protected] tel: 5-2259 263 Mudd Hall Hours: Wed. 3-5 2 Hopkins Hopkins Hopkins BAKER Hopkins Hopkins Hopkins Sensory-motor integration L26 Hearing L25 Spring break Vision 2 L24 Guest Lecture: Harriet Baker L23 Vision 1 L22 Sensory Transduction L21 Touch: principles of sensory systems L20 Schedule 3 20. Touch: Principles of Sensory Function (more or less in sequence) TRANSDUCTION ENCODING ADAPTATION LABELED LINES RECEPTIVE FIELDS INTEGRATION convergence, maps, lateral inhibition, sensory/motor 4 5 SENSES 6 Sense organs tell us….
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2 7 Touch 8 lamellae connective tissue PACINIAN CORPUSCLE 200-2000 microns Gray’s Anatomy 9 ‘Spikes’ from single sensory neuron Adrian, E. D. and K. Umrath (1929) J. Physiol. 68:139 Matthews oscillograph on bromide paper. Edgar Adrian 1932 plantar digital nerve, cat 10 Events 11 Pressure on capsule 12 Pressure on plasma membrane
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3 13 Transduction: mechanosensory channel closed 14 Transduction: open 15 receptor axon pressure spikes initial segment 10 ms generator potential 5 ms TRANSDUCTION ENCODING Lowenstein (’65) TTX electric pressure 1 ms x 15 μ V 16 generator potential adaptation threshold Encoding stimulus ampliutde 17 Encoding stimulus ampliutde increase in burst duration increase in spike rate 18 Amplitude code is a non-linear function of stimulus magnitude. Pressure Peak generator potential (mV) threshold saturation Peak spike rate (s/sec) Spike frequency proportional to generator voltage
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4 19 Integrate and fire model of encoding transduction encoding 20 Integrate and fire simulation Weak current Strong current 21 Neural code for intensity: non-linearity + rate encoding. stimulus
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell.

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L20_2008_TOUCH&PRINCIPLES - Sensory Neurobiology...

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