L25_Hearing - L25. HEARING Simple Cell : orientation...

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1 1 BioNB222 L25. HEARING MARCH 24, 2008 CD HOPKINS 2 BioNB222 LGN CORTEX simple cell retina Simple Cell : orientation selective 3 BioNB222 Complex cell : orientation selective complex simple receptive fields 4 BioNB222 Cortex: Functional Columns Occular dominance Blobs Orientation selective 5 BioNB222 6 BioNB222 Evidence for columns Microelectrode recordings Regional enzyme activity Regional oxygen consumption Optical imaging of Ca ++
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2 7 BioNB222 Electrodes 8 BioNB222 9 BioNB222 10 BioNB222 Enzyme activity Flattened visual cortex. Cytochrome- β stain (shows areas that are metabolically active) After exposure to light in one eye only. 11 BioNB222 Oxygen consumption - Map light reflectance from cortex ( Hi O 2 Low O 2 ) - coarse (regional activity) 12 BioNB222 Optical imaging - Map calcium-dependent fluorescence (calcium levels rise with spike activity) - single cells
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13 BioNB222 14 BioNB222 15 BioNB222 CALCIUM IMAGING: dyes fluoresce only when Ca ++ in present R. Clay Reid, MD, PhD Letter Nature 442 , 925-928 (24 August 2006) Kenichi Ohki 1 , Sooyoung Chung 1 , 3 , Prakash Kara 1 , 3 , Mark Hübener 2 , Tobias Bonhoeffer 2 and R. Clay Reid 1 16 BioNB222 Higher Visual Centers 17 BioNB222 Motion Blindness 18 BioNB222 Face Recognition Functional MRI (measures blood flow). Face matching task.
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell University (Engineering School).

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L25_Hearing - L25. HEARING Simple Cell : orientation...

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