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Lecture29 - BioNB222 Cornell University Spring 2008 Ronald...

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BioNB222 Spring 2008 Cornell University Ronald R. Hoy 1 Lecture 29. Brains Gone Wild: Epilepsy as a catastrophic neural systems failure Reading Assignment: Purves: page 134 (epilepsy and GABA receptors); pp. 201-203 (epilepsy as a systems pathology and the use of the EEG to monitor the bioelectrical origins and course of a seizure, non-invasively, in the clinic. For informative web references see course website. Lecture Outline What does epilepsy have to do with the subject matter in Bio 222 Epilepsy is a disease of the nervous system that is old as the CNS, itself. While epilepsy is a disease of humans, seizure disorders can be found in all animals with a nervous system. While seizures present most dramatically as movement disorders, tonic and/or rhythmic-jerking movements of the limbs and appendages, they are not disorders of the muscles or movement organs, they originate in the CNS. They affect neural function at all levels of physiological analysis: molecular, cellular,
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