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H.%20Baker%20Edited

H.%20Baker%20Edited - Overview of Parkinson's Disease An...

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An Introduction to An Introduction to Parkinson Parkinson ’s Disease: s Disease: Genes and Environment Genes and Environment Harriet Baker, Ph.D. Cornell University March, 2008 Overview of Parkinson’s Disease History Symptoms Underlying cause for symptoms Major types PD Pathology Drug and Surgical Treatments Early symptoms Studies at Burke Medical Research Institute Short History of Parkinson’s Disease • 1817 - James Parkinson published definitive description of PD. • 1958 -1964 - Carlson et al. showed that dopamine is a neurotransmitter. • 1960 - Ehringer and Hornykiewicz showed that loss of dopamine produces PD. • 1967 - George Cotzias introduced L-Dopa therapy for PD. Motor Symptoms of Parkinson’s Disease Tremor Resting tremor - 3-5 Hz. Bradykinesia Slowness of movement Akinesia Inability to initiate movement Postural Instability Loss of balance Rigidity Blank facial expression The Silent Symptoms of PD
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