Lecture41 - 1 Survival Factors Neurotrophic Factors...

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Unformatted text preview: 1 Survival Factors Neurotrophic Factors Involved in the maintenance of neurons In the absence of neurotrophic factors the number of cells undergoing apoptosis increases Nerve Growth Factor (NGF) is a classic neurotrophic factor The Neurotrophins Neurotrophic factors vs. the Neurotrophins Neurotophins are a family of structurally related neurotrophic factors 4 neurotrophins have been identied Nerve Growth Factor (NGF) Brain Derived Neurotrophic Factor (BDNF) NeuroTrophin-3 (NT-3) NeuroTrophin-4/5 (NT-4/5) Ronald Booker, BioNB 222 Spring 2008 Lecture 41 2 Nerve Growth Factor (NGF) NGF is the best described member of the neurotrophin family NGF is required for the survival of neural crest derivatives Sympathetic, dorsal root and superior cervical ganglia Control Anti-NGF superior cervical ganglia Nerve Growth Factor NGF is produced by the target tissue Conrmed using in situ hybridization to localize mRNA expression and immunocytochemistry to localize protein NGF protein but not mRNA is present in sensory and sympathetic neurons Target Neurons Ronald Booker, BioNB 222 Spring 2008 Lecture 41 3 Neurotrophic Factors 1. NGF is bound to specifc receptors 2. NGF is internalized 3. Transported retrogradely3....
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell University (Engineering School).

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Lecture41 - 1 Survival Factors Neurotrophic Factors...

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