Lecture40 - Ronald Booker, BioNB 222 Spring 2008 Lecture 40...

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1 Programmed Cell Death/Apoptosis • The developmental history of a neuron is characterized by a number of discreet steps – Genesis – Migration – Process outgrowth – Cell death is also a part of normal development Specific labels can recognize the dying cells Neuronal Cell Death Stroke/ischemia results in hypoxia a trigger for neuronal apoptosis Cell death following induced Stroke CT scan of a Stroke Victim Ronald Booker, BioNB 222 Spring 2008 Lecture 40
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2 There are two ways that a cell can die Necrosis Uncontrolled process resulting in the rupturing of the cell Occurs following trauma Apoptosis: characterized by the progressive contraction and eventual fragmentation of the cell Membranes remain intact a common feature of normal development Cell Death is a Common Feature of Developing Nervous Systems The level of cell death in the CNS ranges from 0% to 100% In the spinal cord ~50% of the motor neurons die Ronald Booker, BioNB 222 Spring 2008 Lecture 40
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3 Classic Experiments Normally 50% of the motor neurons undergo PCD Eliminate all of the target muscle Double the size of the target muscle The amount of target tissue influences the level of cell death Level of cell loss increases to 70% Level of neuronal death reduced to 30% Molecular Basis of Apoptosis • Apoptosis is also observed in the CNS of invertebrates – Most of the deaths do not appear
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell University (Engineering School).

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Lecture40 - Ronald Booker, BioNB 222 Spring 2008 Lecture 40...

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