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Unformatted text preview: • The neurons of the brain and spinal cord are produced in the Ventricular zone • The young neurons migrate from their place of birth to other regions of the developing CNS The Directed Migration of Neuronal Cells • A migrating neuron resembles a motile fibroblast – The neurons migrate on radial glial cells – Ruffling membrane with lamellipodia and filopodia – Movement involves a series of extensions, attachments and contractions • The force for the contraction is generated by muscle like proteins • How does a neuron know when it is time to move off the radial glial cell? Migration of Neuronal cells Tang migration here Ronald Booker, BioNB 222 Spring 2008 Lecture 38 The Migration of the Neural Crest is Directed • The neural crest cells migrate through a complex environment – A variety of tissue types – Extracellular matrix – Growth factors and other signaling molecules The Directed Movements of Neurons and their Axons • The pattern of connectivity observed in the CNS of an organism is very complex – Axons traverse great distances – Axons interact with specific targets – Growth cones are key to the directed movements of axons • We will examine the cellular and molecular...
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell University (Engineering School).
- Spring '08