lecture%2035a - Presents NEW FRONTIERS Humanizing the...

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Unformatted text preview: Presents NEW FRONTIERS Humanizing the Scientifc Process With HARRIET BAKER, Ph.D Prof. of Neurology and Neuroscience Weill Cornell Medical College Join us for a discussion on Parkinsons disease & the ethical WEDNESDAY 4/14 4:45 6:00 PM Goldwin Smith Kaufman Auditorium Our Goal for Today Review the Basics of learninig and memory DeFne Model System DeFne the molecular basis of learning and Memory Concept: Cell Signaling Learning and Memory Learning The acquisition of a behavior through experience Two General categories of learning 1. Nonassociative Learning Habituation Sensitization 2. Associative Learning Classical Conditioning Operant Conditioning Nonassociative Learning Nonassociative learning : Not dependent on the establishment specifc associations between events Habituation : a decrease in a reFexive response to a repeated, nonnoxious stimulus. Sensitization : an increased reFex response to a wide variety o stimuli or a period o time ater an intense 5 10 15 20 1 2 3 4 5 Response Size Trails Associative learning: the formation of a predictive relationship between two events Classical conditioning: The formation of a predictive relationship between 2 stimuli Conditioned stimulus (CS; bell ) Unconditioned stimulus (UCS; food ) Training: pair the two stimuli Test: present CS alone Memory Cuts Across the Different Categories of Learning 1. Short-term memory= minutes to hours 2. Long-term memory= days, weeks, years Through practice short-term memory is converted to long-term memory Our goal is to defne the cellular and molecular basis oF learning and memory Neurobiologist Faced a challenge in addressing this question using a vertebrate Model Systems in Neurobiology A model system is an experimental setup or organism used in scientifc research to provide inFormation about more complex species Criteria For consideration as a model system Easy/inexpensive to rear Short liFe cycle Physiologically, biochemically, genetically manipulable Promise oF economically important results? Promise oF economically important results?...
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This note was uploaded on 04/30/2008 for the course BIO 2220 taught by Professor Hopkins,c.d. during the Spring '08 term at Cornell University (Engineering School).

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lecture%2035a - Presents NEW FRONTIERS Humanizing the...

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