Lecture39 - Ronald Booker, BioNB 222 Spring 2008 Lecture 39...

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1 Synaptogenesis A key function of the guidance cues is to get the growth cone to its target Once it contacts it is target a synapse develops Here we will examine the critical role neural activity plays in the development and refinement of synapes Synaptogenesis • Synaptic Refinement – The development of a synapse does not end with the formation of a synapse – The maturation of the nervous system involves changes in the arrangement and number of synapses Ronald Booker, BioNB 222 Spring 2008 Lecture 39
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2 Loss of polyneuronal innervation • Initially muscle fibers and neurons are contacted by multiple axons • As development proceeds the extra synapses are lost The Refinement of Synaptic Contacts in the Developing Visual System • In the LGN and layer 4 of the visual cortex of the inputs from the two eyes are segregated Ronald Booker, BioNB 222 Spring 2008 Lecture 39
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3 Ocular Dominance Columns Radioactive tracers a tool for visualizing the ODCs. The tracer is transported transynaptically from the retinal ganglion cells
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Lecture39 - Ronald Booker, BioNB 222 Spring 2008 Lecture 39...

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