SG13 - Gene mutation and repair

SG13 - Gene mutation and repair - involved in a given...

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Study Guide 13 Gene Mutation and Repair After these lectures you should be able to: Answer the following questions from your textbook: o Chapter 17 1, 2, 3, 4, 5, 6, 9, 13, 15, 16, 17, 18, 20, 21 Identify and explain substitutions, insertions and deletions Explain why frame shifts may have such tremendous impacts on proteins Identify and explain the phenotypic effects of mutations Compare and contrast somatic and germ-line mutations. Describe expanding trinucleotide repeats and indicate how they may come about. Compare and contrast the two means of obtaining suppressor mutations. Describe how mutations are made during replication. List and describe five different DNA repair mechanisms. Which of these is found only in prokaryotic organisms? Describe and use a complementation test to determine the number of genes
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Unformatted text preview: involved in a given phenotype. What is a complementation group? WORD LIST base analog lethal mutation point base-excision repair light repair proofreading deletion loss-of-function mutation reverse mutation expanding trinucleotide repeat mismatch repair silent mutation forward mutation missense mutation somatic framshift mutation mutation SOS repair gain-of function mutation mutation frequency spontaneous mutation germ line mutation rate spontaneous mutation induced mutation neutral mutation substitution insertion nonsense mutation suppressor mutation intercalating nucleotide excision repair thymine dimer intergenic suppressor mutation photolyase transition intragenic suppressor mutation photoreactivation transversion...
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This note was uploaded on 05/01/2008 for the course BSCI 222 taught by Professor Gdovin during the Spring '08 term at Maryland.

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