Week 6 Prac Prob Solns - Making Alcohols into Leaving Groups 1 The OH from an alcohol is not a good leaving group Why Good leaving groups are weak bases

Week 6 Prac Prob Solns - Making Alcohols into Leaving...

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OH Br OH Making Alcohols into Leaving Groups Br 1. The OH from an alcohol is not a good leaving group. Why? 2. Provide curved-arrow mechanisms for the following transformations. Why are the mechanisms different? 3. Provide the intermediates and products in the following synthetic sequences. Watchstereochemistry!OH HBr 2. OH NaSH Br SH PBr 3
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