Lecture 12 notes - virus goes directly into cytoplasm chopped up and loaded onto MHC 1 presented on surface 2 create many CTLs specific for the same

Lecture 12 notes - virus goes directly into cytoplasm...

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Lecture 12 notes Tell other immune cells what to do
Clonal Selection of T-Helper Cells o 1) professional antigen presenting cells phagocytose antigen and present epitopes (small bits) on cell surface MHC class 2 molecule: pathogen phagocytosed into phagosome. Processec and presented on cell surface on MHC 2 o 2) create many mature T-helper cells specific for the same epitope on the antigen APC presents epitopes to T cells in lymph node TCR highly specific for epitope. T cell is naïve when its presented. I cell is activated – divides/proliferates to build army = called clonal selection. Each clone is an effector cell. Each clone specific for the exact same epitope. How do CD4 T cells exert their protective role? o Secrete cytokines (protein messages) that tell other cells to do their job Cytokines specific to communicating with b cells and tell them to make AB – IL-4 B cells make antibody Macrophage become even more hostile CD8 become CTL -> kill target cells CD8= cytotoxic T lymphocyte Cant activate CD8 cells without CD4 cells being activated first CD4 T cells are essential for killing intracellular bacteria and viruses and protozoa

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