Lec05 01_18_08 Viruses and pandemics

Lec05 01_18_08 Viruses and pandemics - 5 Flu virus and...

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5. Flu virus and genetic engineering January 18, 2007 Cheung – Chapter 3
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What causes mutations? What causes mutations? Environment Radiation, chemicals, etc. Replication Existing strands templates for new strands DNA polymerase copies with high fidelity 1 mistake/billion bases But …… 10 – 50 trillion cells in body Reducing mistakes Animal gametic cells (germ cells) Set aside early in development fewer divisions More division in sperm more mutations Somatic tissue stem cells
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Central dogma DNA Genetic information mRNA Intermediate information Proteins Biological processes Transcription Translation
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Transcription
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Transcription DNA is used as a template to produce RNA Three major types of RNA mRNAs – contain information for protein sequence rRNA – the backbone of ribosomes (site of protein synthesis) tRNAs – carry amino acids to ribosomes
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Translation
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Ribosome bind to a mRNA tRNAs Carry amino acids to ribosomes Recognize genetic code. Specific tRNAs for each amino acid.
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Lec05 01_18_08 Viruses and pandemics - 5 Flu virus and...

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