Lesson 12 - 10\/6\/16 - DNA Replication Replication builds a duplicate double stranded molecule Requirements Something to copy the template the two

Lesson 12 - 10/6/16 - DNA Replication Replication builds a...

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DNA Replication Replication builds a duplicate, double stranded molecule Requirements: Something to copy - the template, the two individual strands of the parent molecule (semi-conservative replication) Something to do the copying - enzyme called DNa polymerase, incorporates one nucleotide at a time into DNA strand Building blocks - the individual nucleotides to be assembled into the new DNA strand (humans need 6 billion individual units) Replication is complicated - like a big machine DNA polymerase - multimeric enzyme (quaternary structure) Adds single nucleotides to a growing DNA strand Cannot begin a strand - that is, it has to have a short double stranded template at which to begin Always add nucleotides to free 3’OH and always adds in a 5’ → 3’ direction - a new strand grows in that direction Primase - RNA polymerase that generates primer Must be complementary E.Coli model prokaryote has 3 DNA polymerases
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  • Fall '06
  • JRCowles
  • Biology, DNA, DNA Damage, pol III, DNA pol

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