Lec06 01_23_08 Viruses and biotechnology

Lec06 01_23_08 Viruses and biotechnology - 6. Flu virus and...

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6. Flu virus and biotechnology January 23, 2008 Cheung – Chapter 3
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Influenza Virus RNA Virus – 8 RNA separate pieces (segments) Codes for 10 proteins Total size ~10,000 bases Important proteins Hemagglutinin (H): attachment to cell Neuraminidase (N): release and penetration of mucus Polymerase enzymes: RNA RNA Nucleoprotein: binds RNA Tamiflu Inhibits neuraminidase no release from cells
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Influenza Virus
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Electron micrograph of influenza A
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Virus life cycle
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Subtypes of strain A Birds – have combinations of all variants: 15 Hemagglutinin (H1, H2,……H15) 9 Neuraminidase (N1, N2,……N9) Humans – combinations of a few Hemagglutinin = H1,H2, H3 (H5 and H9) Neuraminidase = N1 and N2 Flu strains: Spanish flu: H1N1 Asian flu: H2N2 Hong Kong flu: H3N2
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Typical flu symptoms Symptoms Cough, sore throat, muscle aches, fever, vomiting, headache Breathing problems and pneumonia Cytokine production causes many effects
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Lec06 01_23_08 Viruses and biotechnology - 6. Flu virus and...

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