Lec03 01_14_08 Mutations

Lec03 01_14_08 Mutations - 3. Mutations Another source of...

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3. Mutations 3. Mutations Another source of individual variation Cheung – Chapter s2 & 3
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The importance of sex The importance of sex Most animals/plants: haploid (gametes)/diploid Sexual reproduction Asexual reproduction More efficient/simpler Sex results in enormous variability Genetic lottery Individuals that can survive Genetic experiment Upside and downsides
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Mutations Mutations Changes in bases of DNA 3 Billion bases per haploid genome . changes in proteins Mutations caused by……. . Some mutations beneficial Most deleterious Most recessive Good news: Diploid – hides recessive mutations Sexual reproduction – disclose mutations
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Two genetic diseases Two genetic diseases Cystic fibrosis Tay Sachs Recessive genetic disorders Small mistakes in specific genes Lethal
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Cystic Fibrosis Cystic Fibrosis Occurrence One of most common fatal diseases(1:4,000) Carrier 1 in 31 (Caucasian) 50% die before 30 Cystic fibrosis affects the entire body – but especially lungs Mutation in a chloride channel (CFTR protein) (CFTR = cystic fibrosis transmembrane conductance regulator ) Found in cell membrane
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Biological molecules Biological molecules Large biological molecules are polymers Subunits = monomers Polymers and monomers DNA and RNA – nucleotides (e.g., ATP, GTP) Proteins – amino acids Lipids – fatty acids Polysaccharides – simple sugars (e.g., glucose, galactose)
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What are proteins? What are proteins? Polymers of L- α- amino acids (20) Peptide bond Contain from 3 to >1000 amino acids Sequence determined function ~ 70% of cellular dry weight.
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This note was uploaded on 05/01/2008 for the course BSC 1005 taught by Professor Brist during the Spring '08 term at University of Central Florida.

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Lec03 01_14_08 Mutations - 3. Mutations Another source of...

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