Lec04 01_16_08 Commonality

Lec04 01_16_08 Commonality - 4 Commonality Of viruses and...

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4. Commonality 4. Commonality January 16, 2008 January 16, 2008 Of viruses and humans Cheung – Chapter 3
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Announcements Announcements Free money! Convert your notes to cash and help out another student! See me. Syllabus for the course is on WebCT. I have copies with me.
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Why is cystic fibrosis so common? Why is cystic fibrosis so common? ΔF508 mutation is ~52,000 years old 1:31 Caucasians are carriers Why has this lethal mutation so prevalent? Some mutations protect carriers Heterozygote advantage Example: Sickle cell anemia CFTR protein important for several diseases Cholera toxin requires host CFTR proteins Salmonella typhi (typhoid fever) uses CFTR to enter cells
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Tay Sachs disease Tay Sachs disease Fatal genetic disorder in children Progressive loss of brain function Die between 5 and 7 Carriers -- ~1:300. Higher in some ethnic groups Buildup of membrane lipids in brain Lack of enzyme β -hexosaminidase (HEXA) >90 mutations in HEXA Proteins are functional Misshaped – not processed correctly
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Baby With Tay-Sachs Baby With Tay-Sachs
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Tay-Sachs Gene Mutation Tay-Sachs Gene Mutation
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How can genetic disorders be cured? How can genetic disorders be cured?
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This note was uploaded on 05/01/2008 for the course BSC 1005 taught by Professor Brist during the Spring '08 term at University of Central Florida.

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Lec04 01_16_08 Commonality - 4 Commonality Of viruses and...

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