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Unit 3 Problem Set.pdf - Unit 3: Nuclear Structure and...

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Unit 3: Nuclear Structure and FunctionContent Review QuestionsThis section is designed to help you review the material. Answers can be found more or lesseasily in your notes, on Connect, in the textbook or on the Web. While this background contentknowledge is needed, and will help you on the exam, these review questions are notconsidered ‘exam-style’.A question’s difficulty rating is noted by the 1 (easiest), 2 or 3 (hardest) in brackets beside thequestion. You should expect to look these up as you go.There are no answer keys to questions in this section.We suggestusing these questions astalking points to review & discuss the material with your peers, rather than writing out answersfor each one. It’s ok not to have complete answers for all of these.Topic 3.1Nuclear Structure & Protein Importa. Discuss the relationship between the nuclear envelope and the endoplasmicreticulum. (1)b. What is the functional role of the nuclear lamina? (1)c.One of the key regulatory proteins that initiates the cell division processphosphorylates the proteins of the nuclear lamina. When this happens, theproteins dissociate. From what you already know of the events of mitosis (from1st year) what does this tell you about the role of the nuclear lamina? (3)d. Explain how proteins are targeted to the nucleus. Specifically, explain the roles ofthe internal targeting sequence encoded in the protein, the specific receptor thatrecognizes these targeting sequences and the process by which the complex ofnuclear destined protein and its receptor interact with components of the nuclearpore to enter the nucleus. (2)e. Describe the three major structural elements of the nucleolus. (1)f.Sketch a nucleus on your paper. Draw and label the...NucleolusNuclear envelopeNuclear poresNuclear laminaHeterochromatinEuchromatinTopic 3.2Chromatin and Chromosomesa. Find structures of the 5 major nucleic acids in your textbook or online. Identify thefollowing features on the structures (2):The ribose sugar. What is the major difference between this sugar in DNA & RNA?The phosphate group(s). Identify the bond broken when a nucleotide tri-phosphate isincorporated into DNA or RNA?The purine or pyrimidine ring. How do these structures contribute to base stackingand 3D structure of the final molecule?

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Term
Spring
Professor
Unknown
Tags
DNA, Cell nucleus, Micrococcal Nuclease

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