BME402_HW3_Solutions

# BME402_HW3_Solutions - BME 402 Homework 3 Due 11am...

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BME 402 Homework 3 Due 11am, 2/8/07 Hodgkin-Huxley What makes an action potential? You should be able to draw what is happening to g Na and g K during an AP in either current clamp or voltage clamp mode. Given the plots of n , τ n , etc., you should be able to plot exactly, by inspection (i.e. without calculation), the time course of n, m, or h in response to a series of constant voltage steps. Understand the notion of a gating particle, and why HH tried multiplying variables together to predict channel open probabilities. You should know how to write or derive the 4 equations of the HH model, and how to set the equations up for numerical integration using the forware Euler method. You should be able to explain why the voltage clamp is useful in studying ionic currents from an experimental point of view, and you should know the plotting convention for inward vs. outward currents. Know the names of the agents that block voltage dependent Na + and K + channels and the Na-K pump, and be able to describe or draw their effects on the action potential (short and long term). Homework question: 1. In a voltage-clamp experiment, you clamp the membrane of an excitable neuron from an initial holding potential of -100 mV (where the cell has been held for a long time) to both of the following 2 values in separate experiments: 0 mV and +80 mV, and then back to -100 mV in each case after 2 ms. Assuming E

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