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Neurophysiology Notes Oct 19

Neurophysiology Notes Oct 19 - Neurophysiology...

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Neurophysiology October 19, 2007 Neuromuscular Junction: as a model is simpler than central synapses Neuromuscular Junction -EPP is ~70 mV and typically elicits an action potential -muscle fibers are innervated by only one motor neuron -excitatory -one transmitter, Ach(in vertebrates) Central Synapses -EPSP typically ~.2-1mV, so neurons must integrate many inputs to reach threshold - receive 100’s-1000’s of inputs -can be both excitatory and inhibitory -many different transmitters Why might the synaptic potentials produced in central neurons be smaller than in the end plate potential? -not as much neurotransmitter released at the central synapses. -less voltage gated Calcium channels Some Central Neurotransmitters Excitatory : Glutamate, apartate Inhibitory: GABA, Glycine Both: Ach, norepinephrine, serotonin, dopamine How can these elicit different responses? Excitatory, inhibitory, or both? The effects are dependent on what type of receptor these transmitters attach to.
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