Neurophysiology Notes Oct 12

Neurophysiology Notes Oct 12 - Neurophysiology October12,...

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Neurophysiology October12, 2007 Why use gap junctions? -Fast speed of propagation -Synchronize activity in cells -Transmissions of metabolic signals between cells. -Always excitatory Chemical Synapses -Gap junction between cells of 20-40 nm(synaptic cleft) -Involves release of neurotransmitter by presynaptic cell (exocytosis) -Neurotransmitter crosses gap and binds to receptor in postsynaptic cell -Can be excitatory or inhibitory -More flexible and tend to produce more complex behavior -Can undergo changes in effectiveness (plasticity) -Can provide amplification of signal allowing small presynaptic cell to alter membrane potential of large postsynaptic cell -often a much better option in the nervous system. Need mechanism for: -synthesizing neurotransmitter and packaging into synaptic vesicles for storage -getting synaptic vesicles to release neurotransmitter at the appropriate time -producing a response in postsynaptic cell. Neurotransmitters -Different neurons use different neurotransmitter substances -some are small molecule neurotransmitters and some are neuroactive peptides. Both types are store in vesicles—there are also gaseous neurotransmitters -These neurotransmitters differ in their synthesis pathways -small molecule neurotransmitters are synthesized at the synaptic terminal and
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This note was uploaded on 05/03/2008 for the course IPHY 4720 taught by Professor Casagrand during the Fall '07 term at Colorado.

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Neurophysiology Notes Oct 12 - Neurophysiology October12,...

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