Neurophysiology Notes sept 21

Neurophysiology Notes sept 21 - Neurophysiology Notes 1....

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Neurophysiology Notes 1. The action potential consists of several phases resulting from the sequential opening and closing of voltage gated ion channels, changes in the conductance which allows the changes in current. -Resting membrane potential at about -65 mV, then -Depolarization –causes the opening of voltage gated channels, allowing sodium back into the cell. -Hyperpolarization- the cell starts to become more negative than it was at the depolarization. 4. The voltage clamp is a negative feedback technique that allows experimenter to “clamp” membrane potential (Vm) at predetermined levels (command potential, CP) and measure membrane currents at that flow at that potential -note patch clamp is a refinement of the voltage clamp Voltage clamp makes it possible to determine the effect of Vm on membrane conductance for different ions How? First voltage clamp is a current generator 1. CP vrest change the membrane potential (0mV, -25 mV, -50 mV) 2. Inject (positive ions)current into the change in membrane potential
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/03/2008 for the course IPHY 4720 taught by Professor Casagrand during the Fall '07 term at Colorado.

Page1 / 2

Neurophysiology Notes sept 21 - Neurophysiology Notes 1....

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online