Cancer%20slide%20show%202008%20cps%20version%20revised

Cancer%20slide%20show%202008%20cps%20version%20revised -...

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Cancer Uncontrolled cell division
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Cancer incidence and mortality in the United States in 2004
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Testing a compound for possibility of being a mutagen . What is the difference between the plates with and without the potential mutagen? Does this suggest that cancer cells are examples of Darwinian selection? Why or why not?
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Why do we owe so much to this woman?
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Tumor cells are transformed cells. What are the characteristics of transformed cells?
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Properties of transformed [cancer] cells: 1. Lack of density dependent inhibition of cell growth 2. Reduced requirement for Growth Factors 3. Loss of contact inhibition 4. Alterations in the ECM and Cytoskeleton 5. Protease secretion especially metalloproteinases. 6. Secretion of growth factors promoting angiogenesis 7. Failure of normal differentiation 8. Failure to undergo Programmed cell death. [Apoptosis] 9. Transformed cell can cause tumors when injected into susceptible mice. 10. Transformed cells have glycoproteins and glycolipids in their plasma membranes making their membranes more fluid than normal cells. 11. Aneuploidy: Aberrant chromosome number.
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Why do cancer cells grow in the absence of serum growth factors?
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Do viruses cause cancer?
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Retroviruses are a family of RNA viruses that cause cancer in a variety of animal species. In order to replicate within a host cell the virus makes a DNA copy of its genome using the pol gene, a reverse transcriptase, and integrates into the host genome using the pol integrase. The integrated DNA then makes RNA copies for the replicating virus. Not all retroviruses cause cancer; why do some viruses cause cellular transformation?
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Infection of cultured cells with RSV results in cellular transformation and virus replication. Infection of cultured cells with ALV results in no transformation, but virus replication. What is the significance of this result? What are the characteristics of transformed cells?
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To replicate the viruses need gag, pol and env genes. What is the origin of the
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This note was uploaded on 05/03/2008 for the course CELL 210 taught by Professor Lyman during the Spring '08 term at SUNY Stony Brook.

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Cancer%20slide%20show%202008%20cps%20version%20revised -...

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