11 - Bio 102 10:13:00 ← Mutations • Heritable change in...

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Unformatted text preview: Bio 102 11/02/2008 10:13:00 ← Mutations • Heritable change in gene • Any self replicating change in genetic material • Gene mutations – point mutations ← Chromosomes: Inversions, deletions, etc. ← 1) Active site of enzyme ← 2) Alter hydrophilic or hydrophobic amino acids ← 3) Disturb internal bonding of amino acids in protein ← How frequent is mutation? • 1-500 per million ← Huntington’s chorea 1x10^-6 ← Tissue culture ← T2 bactiophase ← DNA polymerase ← Some genes have higher mutation rates than others ← 1) DNA corrective mechanisms ← 2) Mutation is typically a random event • even increase frequency by x-rays • UV chemical interactions increase frequency ← 3) Mutation is usually harmful • Exception that proves the rule • Essential for evolutionary progress ← Viruses have poor error correction • Good for them bad for us ← Errors in chromosomal inheritance •...
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This note was uploaded on 03/03/2008 for the course BIO G 102 taught by Professor Walcott during the Spring '08 term at Cornell.

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11 - Bio 102 10:13:00 ← Mutations • Heritable change in...

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