11 - Bio 102 Mutations Heritable change in gene Any self...

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Bio 102 11/02/2008 10:13:00 Mutations Heritable change in gene Any self replicating change in genetic material Gene mutations – point mutations Chromosomes: Inversions, deletions, etc. 1) Active site of enzyme 2) Alter hydrophilic or hydrophobic amino acids 3) Disturb internal bonding of amino acids in protein How frequent is mutation? 1-500 per million Huntington’s chorea 1x10^-6 Tissue culture T2 bactiophase DNA polymerase Some genes have higher mutation rates than others 1) DNA corrective mechanisms 2) Mutation is typically a random event even increase frequency by x-rays UV chemical interactions increase frequency 3) Mutation is usually harmful Exception that proves the rule Essential for evolutionary progress Viruses have poor error correction Good for them bad for us Errors in chromosomal inheritance
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