CHEN 1000 Biotech Lecture 3 Notes

CHEN 1000 Biotech Lecture 3 Notes - Central Dogma of...

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Central Dogma of Biology From DNA to Genetic Engineering • DNA. Information. – polymer of nucleotides – Contains information required for cell to survive and replicate – Enzymes (proteins) can make copies, cut, and paste back together DNA • RNA. Messenger - -from DNA - Protein – Polymer of nucleotides • Proteins. – polymer of Amino-acids – The workers. What do you need to know to understand Genetic Engineering? http://www. accessexcellence .org/RC/VL/GG/central.html (1) transcription: the code from the gene is copied by creating a piece of messenger RNA (mRNA) that contains the code. (2) translation: the piece of mRNA is used as a template by a ribosome to create the protein. The information from each gene is used to create a protein in two steps Decoding DNA: the “Central Dogma” of Molecular Biology promotor region termination sequence Transcription A complement of a gene is created in a piece of mRNA • dsDNA is locally split apart • complementary nucleotides attach to ssDNA (substituting U for T) RNA polymerase strings together the nucleotides into functional mRNA • In RNA, uracil (U) is used instead of thymine (T) How does RNA polymerase “know” where the gene starts and ends? • The start of each gene is labeled by a
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CHEN 1000 Biotech Lecture 3 Notes - Central Dogma of...

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