PPT_Chapter_57_updated - Drugs Affecting Gastrointestinal Secretions Chapter 57 Copyright 2013 Wolters Kluwer Health | Lippincott Williams Wilkins

PPT_Chapter_57_updated - Drugs Affecting Gastrointestinal...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs Affecting Gastrointestinal Secretions Chapter 57
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Underlying Causes of GI Disorders Dietary Excess Stress Hiatal Hernia Esophageal Reflux Adverse Drug Effects Peptic Ulcer Disease
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Effect of Drugs on GI Secretions Decrease GI secretory activity Block the action of GI secretions Form protective coverings on the GI lining to prevent erosion from GI secretions Replace missing GI enzymes that the GI tract or ancillary glands and organs can no longer produce
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs Used in the Treatment of GERD & Ulcers Histamine-2 (H 2 ) Antagonists Block the release of hydrochloric acid in response to gastrin Antacids Interact with acids at the chemical level to neutralize them Proton Pump Inhibitors Suppress the secretion of hydrochloric acid into the lumen of the stomach
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs Used in the Treatment of GERD & Ulcers (cont.) Antipeptic Agents Coat any injured area in the stomach to prevent further injury from acid Prostaglandins Inhibit the secretion of gastrin and increase the secretion of the mucous lining of the stomach, providing a buffer
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Sites of Actions of Drugs Affecting Gastrointestinal Secretions
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Peptic Ulcer Disease Definition Erosions in the lining of the stomach and adjacent areas of the GI tract Symptoms Gnawing, burning pain, often occurring after meals Cause Bacterial infection by Helicobacter pylori bacteria
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Histamine-2 (H 2 ) Antagonists Cimetidine (Tagamet) Famotidine (Pepcid) Nizatidine (Axid) Ranitidine (Zantac)
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Histamine-2 (H 2 ) Antagonists (cont.) Indications (cont.) Treatment of erosive gastroesophageal reflux Relief of symptoms of heartburn, acid indigestion, and sour stomach (OTC preparations) Pharmacokinetics Readily absorbed after oral administration Metabolized in the liver and excreted in urine Contraindications Known allergy
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
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