PPT_Chapter_58_updated - Drugs Affecting Gastrointestinal Motility Chapter 58 Copyright 2013 Wolters Kluwer Health | Lippincott Williams Wilkins Actions

PPT_Chapter_58_updated - Drugs Affecting Gastrointestinal...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs Affecting Gastrointestinal Motility Chapter 58
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Actions of Drugs Used to Affect Motor Activity of the GI Tract Speed up or improve movement of intestinal contents when movement becomes slow or sluggish (constipation) Increase the tone of the GI tract and stimulate motility throughout the system Decrease movement along the GI tract when rapid movement decreases the time for absorption of nutrients (diarrhea)
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Sites of Action of Drugs Affecting GI Motility
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Types of Laxatives (Cathartics) Chemical Stimulants Chemically irritate the lining of the GI tract Bulk Stimulants Cause the fecal matter to increase in bulk Lubricants Help the intestinal contents move more smoothly
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Types of Chemical Stimulants Cascara (Generic): Reliable agent that leads to intestinal evacuation Senna ( Senokot ): Reliable drug, similar to cascara (OTC) Castor Oil ( Neoloid ): Old standby for thorough evacuation of the intestine Bisacodyl ( Dulcolax ): Very popular OTC laxative
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Types of Bulk Stimulants Magnesium Sulfate ( Epsom Salts ) Magnesium Citrate ( Citrate of Magnesia ) Magnesium Hydroxide ( Milk of Magnesia ) Lactulose ( Chronulac ) Polycarbophil ( FiberCon ) Polyethylene glycol-electrolyte solution (GoLYTELY, MiraLAX) Psyllium ( Metamucil )
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Types of Lubricating Laxatives Docusate ( Colace ) Has a detergent action on the surface of the intestinal bolus, making a softer stool Glycerin ( Sani-Supp ) Hyperosmolar laxative used to gently evacuate the rectum without systemic effects higher in the GI tract Mineral Oil ( Agoral Plain ) Forms a slippery coat on the contents of the intestinal tract
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Other Laxatives Methylnaltrexone (Relistor) Box 58-2 p. 982 Approved in 2008 treatment of opioid-induced constipation Works in the periphery and is a selective antagonist to the opioids binding at the mu-receptor Given by daily SC injections
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