Literature Review 2

Literature Review 2 - Literature Review 2 Kruger, T.,...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Literature Review 2 Kruger, T., etal., Plastic components affect the activation of the arylhydrocarbon and the androgen receptor, Toxicology(2008),doi:10.1016/j.tox.2007.12.028 Abstract/Introduction: The long-term goal of this study is to determine whether certain xenobiotic compounds produced in manufacture of various products are harmful to human health. Previous studies have indicated that many of these compounds can act as endocrine disrupters by binding to hormone receptors. In this paper, the authors explore the effect of plastic components on arylhydrocarbon receptor (AhR) in mouse hepatoma cells and androgen receptor (AR) in Chinese Hamster Ovary (CHO) cells. Methods: A chemically activated luciferase gene expression bioassay (CALUX) was used to measure the activity of AhR or AR in different cell lines when exposed to suspected endocrine-disrupting chemicals (EDCs). Using cell lines as a model is convenient for studying molecular events. Activation of a receptor is most likely similar in the cell line and the entire organism. This provides a cheap, fast method for screening multiple chemicals for effects, which was the goal of this study. However, this preliminary data
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 2

Literature Review 2 - Literature Review 2 Kruger, T.,...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online