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Literature Review 2

Literature Review 2 - Literature Review 2 Kruger T etal...

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Literature Review 2 Kruger, T., etal., Plastic components affect the activation of the arylhydrocarbon and the androgen receptor, Toxicology(2008),doi:10.1016/j.tox.2007.12.028 Abstract/Introduction: The long-term goal of this study is to determine whether certain xenobiotic compounds produced in manufacture of various products are harmful to human health. Previous studies have indicated that many of these compounds can act as endocrine disrupters by binding to hormone receptors. In this paper, the authors explore the effect of plastic components on arylhydrocarbon receptor (AhR) in mouse hepatoma cells and androgen receptor (AR) in Chinese Hamster Ovary (CHO) cells. Methods: A chemically activated luciferase gene expression bioassay (CALUX) was used to measure the activity of AhR or AR in different cell lines when exposed to suspected endocrine-disrupting chemicals (EDCs). Using cell lines as a model is convenient for studying molecular events. Activation of a receptor is most likely similar in the cell line and the entire organism. This provides a cheap, fast method for screening multiple chemicals for effects, which was the goal of this study.
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