nifedipine - Name/bks_53161_deglins_md_disk/nifedipine...

This preview shows page 1 - 2 out of 3 pages.

Canadian drug name.Genetic Implication.CAPITALS indicate life-threatening, underlinesindicate most frequent.StrikethroughDiscontinued.1NIFEdipine(nye-fed-i-peen)AdalatCC,AdalatXL,AfeditabCR,Procardia,ProcardiaXLClassificationTherapeutic:antianginals,antihypertensivesPharmacologic:calcium channel blockersPregnancy Category CIndicationsManagement of: Hypertension (extended-release only), Angina pectoris, Vasospastic(Prinzmetal’s) angina.Unlabeled Use:Prevention of migraine headache. Man-agement of HF or cardiomyopathy.ActionInhibits calcium transport into myocardial and vascular smooth muscle cells, result-ing in inhibition of excitation-contraction coupling and subsequent contraction.Therapeutic Effects:Systemic vasodilation, resulting in decreased BP. Coronaryvasodilation, resulting in decreased frequency and severity of attacks of angina.PharmacokineticsAbsorption:Well absorbed after oral administration, but large amounts are rap-idly metabolized (primarily by CYP3A4 enzyme system), resulting inpbioavailability(45–70%); bioavailability isq(80%) with long-acting (CC, PA, XL) forms.Distribution:Unknown.ProteinBinding:92–98%.MetabolismandExcretion:Mostly metabolized by the liver.Half-life:2–5 hr.TIME/ACTION PROFILEROUTEONSETPEAKDURATIONPO20 minunknown6–8 hrPO–PAunknown4 hr12 hrPO–CC, PA, XLunknown6 hr24 hrContraindications/PrecautionsContraindicated in:Hypersensitivity; Sick sinus syndrome; 2nd- or 3rd-degreeAV block (unless an artificial pacemaker is in place); Systolic BP90 mm Hg; Coad-ministration with grapefruit juice, rifampin, rifabutin, phenobarbital, phenytoin, car-bamazepine, or St. John’s wort.UseCautiouslyin:Severe hepatic impairment (pdose recommended);Historyofporphyria; Severe renal impairment (pdose may be necessary); History of seriousventricular arrhythmias or HF;OB, Lactation:Use only if potential benefit justifiespotential risks;Pedi:Safety not established;Geri:Short-acting forms appear onBeers list due toqrisk of hypotension and constipation (pdose recommended); alsoassociated withqincidence of falls.AdverseReactions/Side EffectsCNS:headache, abnormal dreams, anxiety, confusion, dizziness, drowsiness, jitteri-ness, nervousness, psychiatric disturbances, weakness.

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture