Chapter 15 - Chapter 15 Mechanisms of Pathogenicity...

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Chapter 15 Mechanisms of Pathogenicity Pathogen- organism that causes a specific disease in a host Virulence- measure of the degree of pathogenicity, or infectiveness and severity of disease Barriers to Infection/Portal of Entry for pathogens 1. Intact skin or mucous membranes A. Primary route for respiratory infections is penetration of mucous membranes; diseases contracted by this route include the common cold, bacterial and viral pneumonias, tuberculosis, influenza, measles, and smallpox. B. Digestive tract infections include poliomyelitis, hepatitis A, typhoid, amoebic dysentery, shigellosis, and cholera. C. Reproductive tract infections include syphilis, gonorrhea, chlamydia, and HIV/AIDS 2. Parenteral route A. Punctures of the skin- leads to infections with tetanus, Rocky mountain spotted fever, rabies, B. Surgical incisions, drains, ostomies, tracheotomies- common routes of infection for nosocomial Infections Factors Influencing Virulence upon exposure to a Disease Agent 1. Preferred portal of entry- each pathogen has a primary route of entry that can lead to a successful infection
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2. Microbial dose- the number of organisms entering via the
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This note was uploaded on 05/05/2008 for the course BIOL 357 taught by Professor Kalia during the Spring '08 term at University of Louisville.

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Chapter 15 - Chapter 15 Mechanisms of Pathogenicity...

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