Chapter 20 - Antimicrobial Drugs Chemical compounds that...

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Antimicrobial Drugs Chemical compounds that inhibit the growth of microorganisms are called antimicrobials. Modes of Action Inhibition of: Cell Wall Synthesis Protein Synthesis Nucleic Acid Synthesis Metabolic Pathway/s Cell Wall Synthesis Inhibitors: Penicillins- Products of Penicillium notatum; susceptible to penicillinase enzymes. Inhibit peptidoglycan synthesis Bacitracin - effective primarily against gram+ bacteria, is used as topical antibiotic Inhibit peptidoglycan synthesis Vancomycin - inhibits peptidoglycan synthesis; used against penicillinase-producing Staphlococci. Inhibit peptidoglycan synthesis Isoizid - inhibits mycolic acid synthesis in Mycobacteria Inhibitors of Protein Synthesis: Act by inhibiting the attachment of m-RNA to the 30s unit of the ribosome, or codon recognition, or movement of the m-RNA within the ribosome complex to expose triplet codons for translation Chloramphenico l- broad–spectrum antibiotic that affects protein synthesis. Bonds to the 50S ribosome and inhibits formation of peptide bonds
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Chapter 20 - Antimicrobial Drugs Chemical compounds that...

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