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Leech Projects 2006

An Introduction to Bioinformatics Algorithms (Computational Molecular Biology)

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ON-GOING PROJECTS IN THE MACAGNO LABORATORY AT UCSD HIRUDO MEDICINALIS GENOMICS, DEVELOPMENT, NEURAL STRUCTURE AND NEURAL FUNCTION
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The leech CNS is comprised of a head ganglion, 21 midbody segmental ganglia and a tail ganglion. Each midbody ganglion contains about 400 neurons and connects to adjacent ganglia and to the internal organs.
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Schematic of a segmental ganglion from its ventral aspect HE HE ~185 bilateral pairs ~30 unpaired
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Embryos are large (6-8 mm) and easy to manipulate
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Living Dissected Leech Embryo Head CNS Tail ? ?
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Embryonic sensory neuron extending through ventrum to innervate dorsum
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Section of Chick Spinal Cord from Ramon y Cajal (circa 1890)
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MACAGNO LABORATORY Project 1: Functions of receptor phosphatases in development Project 2: Dynamics of process outgrowth and the cytoskeleton Project 3: Role of netrin in neuronal sensory tiling Project 4: Expression and functions of Innexins Project 5: Gene expression profiles of identified neurons COLLABORATIONS 1: Creation of Hirudo
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