Leech Projects 2006

An Introduction to Bioinformatics Algorithms (Computational Molecular Biology)

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Unformatted text preview: ON-GOING PROJECTS IN THE MACAGNO LABORATORY AT UCSDHIRUDO MEDICINALISGENOMICS, DEVELOPMENT, NEURAL STRUCTURE AND NEURAL FUNCTIONThe leech CNS is comprised of a head ganglion, 21 midbody segmental ganglia and a tail ganglion. Each midbody ganglion contains about 400 neurons and connects to adjacent ganglia and to the internal organs. Schematic of a segmental ganglion from its ventral aspectHEHE~185 bilateral pairs~30 unpairedEmbryos are large (6-8 mm) and easy to manipulateLiving Dissected Leech EmbryoHeadCNSTail??Embryonic sensory neuron extending through ventrum to innervate dorsumSection of Chick Spinal Cord from Ramon y Cajal (circa 1890)MACAGNO LABORATORYProject 1: Functions of receptor phosphatases in developmentProject 2: Dynamics of process outgrowth and the cytoskeletonProject 3: Role of netrin in neuronal sensory tilingProject 4: Expression and functions of InnexinsProject 5: Gene expression profiles of identified neuronsCOLLABORATIONS1: Creation of HirudoEST libraries and gene microarrays...
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Leech Projects 2006 - ON-GOING PROJECTS IN THE MACAGNO...

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