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Hippocampus Lecture - HIPPOCAMPUS 1 Brief Limbic system...

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HIPPOCAMPUS 1. Brief Limbic system overview 2. Hippocampal formation: function and connectivity a) Organization and cell types b) Dentate c) CA3 d) CA1 3. Physiological properties 4. Pharmacological properties
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1. LIMBIC SYSTEM: 1937 James Papez : cortical machinery for feeling involves Limbic Lobe, a region identified by Paul Broca. Cingulate gyrus Entorhinal cortex Parrahippocampal gyrus Hippocampal formation: hippocampus, dentate, subiculum (pre and para), entorhinal cortex Septal nuclei Hypothalamus Mammilary bodies Thalamus Ventral basal ganglia
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Functions: - allows to distinguish between the agreeable/disagreeable - specific affective functions : females nursing and protecting their toddlers; developing lucid behaviors (playful moods) - emotions and feelings, like wrath, fright, passion, love, hate, joy and sadness (are mammalian inventions); FEAR! - This system is also responsible for some aspects of personal identity and for important functions related to memory
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2. HIPPOCAMPUS (Ammon’s Horn) Sea Horse, Hippocampus ramulosus . Photograph by Robert Jones (Trowbridge, Wiltshire, U.K.) Ammon was an ancient Egyptian god. He was depicted as a human with a ram's head. He was one of the chief gods (later, supreme deity) and was adopted by the Greeks as Zeus and the Roman’s as Jupiter
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Hippocampus - one of the most famed and studied structures in the brain: 1) Distinctive and easily identifiable gross structure and histological appearance - laminar structure with one distinct cell layer 2) Plays an important role in learning and memory - H.M. (1957 Scoville and Milner) 3) High susceptibility to seizures - other neuropathologies - Alzheimer’s and Schizophrenia - ischemia, anoxia http://synapses.mcg.edu/index.asp
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S-T septo-temporal axis TRANS Transverse axis DG - Dentage Gyrus CA3, CA2, CA1 areas S - Subiculum pp - perforant path fromentorhinal cortex mf - mossy fibers from granule cells sc - Schaffer collateral connections from CA3 to CA1 HIPPOCAMPAL LAYERS
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Hippocampus Caudal
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Str. ORIENS
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