Ebola Virus - 1 Brian Miller 5 May 2008 New Emerging...

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Brian Miller 5 May 2008 New & Emerging Diseases Professor Cluett Ebola Virus The Ebola [EBO] virus [discovered in 1976 in the Ebola River Basin in  Zaire, where the virus gets its name] is one of two viruses that make up the  virus family Filoviridae, which cause severe hemorrhagic fever in humans and  nonhuman primates. 1  There are four subtypes of EBO virus that have been  discovered: Ebola-Zaire, Ebola-Sudan, Ebola-Ivory, and Ebola-Reston [the only  form that does not cause disease in humans). 2  The range of hosts of the Ebola  virus extends to humans and nonhuman primates. According to the Center for  Disease Control and Prevention, “the exact origin, locations, and natural habitat  (known as the  natural reservoir ) of Ebola virus remain unknown. 3 Ebola’s life cycle is an almost direct reversal of “the central dogma” of  molecular biology. The virus attaches to host receptors and is endocytosed into  the vesicles of the host cell. Next, the virus and vesicle membrane fuse, during  1 Center for Disease Control, Questions and Answers about Ebola Hemorrhagic Fever . <http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebola/qa.htm#top> Modified: November 18, 2005. Retrieved: Saturday May 3, 2005. [Hereafter cited as “CDC.org”] 2 CDC.gov 3 CDC.gov 1
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which the nucleocapsid is released into the host cell’s cytoplasm where EBO  ssRNA is used as a template for the synthesis of mRNA. Then, the EBO virus  uses the host cell’s machinery for the translation of mRNA into viral proteins. As  viral protein levels rise, translation is replaced by DNA replication, and the viral  proteins are encapsidated. Finally, through budding of the cell so as to avoid cell 
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