Lecture_2B_-_Protein_function_S2008

Lecture_2B_-_Protein_function_S2008 - Transduction of...

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Heme = protoporphyrin + iron atom
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His as a fifth coordinate for heme
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Structure of myoglobin
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O 2 binding to myoglobin
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Orientation of O 2 and CO 2 binding in myoglobin
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Schematic of O 2 -binding site
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Comparison of hemoglobin and myoglobin
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Change in quaternary structure of Hb upon oxygenation
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Oxygenation moves iron atom into plane of the heme
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Sigmoidal binding curve
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O 2 binds cooperatively to Hb
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Role of Hb in O 2 and CO 2 transport
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2,3-BPG decreases affinity for O 2
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2,3-BPG binding to hemoglobin
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O 2 affinity for fetal hemoglobin
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Sickle cell anemia
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Normal vs. sickle-cell hemoglobin
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Immune response
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MHC proteins
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MHC I
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I mmunoglobulins (antibodies)
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Role of IgG
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Regulatory molecules: Ex. epinephrine
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Unformatted text preview: Transduction of epinephrine signal G proteins cAMP as intracellular secondary messenger Glucagon Epinephrine/Glucagon cascade Insulin Regulation by insulin Regulation of glycogen synthase Diabetes mellitus (DM) Type I = insulin dependent (IDDM) Type II = non-insulin dependent (NIDDM) Myosin Structure of myosin Myosin and actin Structure of skeletal muscle Sliding filament model Hydrolysis of ATP drives association/dissociation of actin/myosin Proposed mechanism Tropomyosin and troponin Troponin C Source of ATP for muscle contraction is glycolysis 1 glucose => 2 pyruvate In muscle...
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This note was uploaded on 05/10/2008 for the course BIOCH 301 taught by Professor Smith during the Spring '08 term at Clemson.

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Lecture_2B_-_Protein_function_S2008 - Transduction of...

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