Lecture_4C_-_TCA_cycle_S2008

Lecture_4C_-_TCA_cycle_S2008 - (2) Formation of isocitrate...

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Production of acetyl-CoA (activated acetate)
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Synthesis of acetyl-CoA
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Pyruvate dehydrogenase is complex
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Pyruvate to acetyl-CoA Pyruvate + TPP- E1 hydroxyethyl-TPP- E1 + CO 2 hydroxyethyl-TPP- E1 + lipoate- E2 acetyllipoamide- E2 + TPP- E1 acetyllipoamide- E2 + CoA-SH acetyl-CoA + dihydrolipoyl- E2 dihydrolipoyl- E2 + FAD- E3 lipoate- E2 + FADH 2 - E3 FADH 2 - E3 + NAD + FAD- E3 + NADH + H + Pyruvate + CoA-SH + NAD + CO 2 + acetyl-CoA + NADH + H +
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Pyruvate dehydrogenase is a complex
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Citric acid cycle
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(1) Formation of citrate
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Unformatted text preview: (2) Formation of isocitrate via cis-aconitate (3) Oxidation of isocitrate to -ketoglutarate and CO 2 (4) Oxidation of -ketoglutarate to succinyl-CoA and CO 2 (5) Conversion of succinyl-CoA to succinate (6) Oxidation of succinate to fumarate (7) Hydration of fumarate to malate (8) Oxidation of malate to oxaloacetate One turn of citric acid cycle yields: Role of citric acid cycle in anabolism Regulation of metabolite flow...
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This note was uploaded on 05/10/2008 for the course BIOCH 301 taught by Professor Smith during the Spring '08 term at Clemson.

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Lecture_4C_-_TCA_cycle_S2008 - (2) Formation of isocitrate...

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