ENTX HW#2 - Case Study#2 Starting Material Ending Material...

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Case Study #2 Starting Material Ending Material A 25-year-old female presented with pregnancy although daily regiments of birth control pills (ethynyl estradiol) were consumed. The patient began a daily regimen of St. John’s Wort several weeks prior to the pregnancy observation. St. John’s Wort is a supplement that is commonly used for the treatment of anxiety and mild to moderate depression. (1) Many clinical trials have been done to try and prove the effectiveness of St. John’s Wort for the treatment of depression. Many of these tests have compared the supplement to placebos or pharmaceutical antidepressants. (2) In St. John’s Wort is a chemical called Hyperforin. Hyperforin is responsible for the activation of PXR. (4) PXR is a regulator that increases the activity of CYP3A4 which metabolizes ethynyl estradiol. (3) PXR binds to CYP3A4, which is found in DNA. Through the central dogma, DNA makes RNA which makes proteins, PXR induces production of CYP3A4. The
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