Lecture 7 Minicollagens Oct 3, 2016

Lecture 7 Minicollagens Oct 3, 2016 - Lecture Topics L1...

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1 Lecture Topics L1 Sept 12 Intracellular processing and secretion of ECM molecules L2 Sept 14 Molecular organization and classification of collagens: fibril-forming collagens. Type I collagen and connective tissue defects due to the improper assembly of type I collagen In the ER: scurvy and osteogenesis imperfecta. L3 Sept 19 Supramolecular assembly and cross-linking of type I collagen molecules. Dermatosparaxis disease L4 Sept 21 Connective tissue collagen defects: Ehlers-Danlos syndrome Basal laminae/basement membranes: network-forming type IV collagen L5 Sept 26 Role of basal laminae in epithelial morphogenesis: focus on collagen IV. L6 Sept 28 Role of collagen IV in kidney filtration Type VII collagens and anchoring fibrils in the dermal-epidermal junction zone and epidermolysis bullosa FACIT collagens and epiphyseal dysplasia Lec 7 Oct 3 Minicollagens and jelly fish nematocysts
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2 A severe collagen XI-null fibril phenotype is enhanced by reduction in collagen V, indicating synergistic , not redundant, regulatory roles. Text verbatim from Wenstrup et al. JBC 286, 23: 20455–20465 WT Col11 α 1-/- Col11 α 1-/-; Col5 α 1+/-
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3 Text verbatim from Wenstrup et al. JBC 286, 23: 20455–20465 FIGURE 5. A severe collagen XI-null fibril phenotype is enhanced by reduction in collagen V, indicating synergistic regulatory roles. The loss of collagen XI in Col11 α 1-/- tendons (B and C) is associated with abnormally large fibrils with aberrant structures (arrows) compared with wild type controls (A). A deficiency in collagen XI coupled with a
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  • Fall '09
  • RINGUETTE
  • Collagen, eds, connective tissue collagen, collagen XI-null fibril, severe collagen XI-null, Abnormal collagen fibril

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