Lecture Topics L1 Sept 12 Intracellular processing and...

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1 Lecture Topics L1 Sept 12 Intracellular processing and secretion of ECM molecules L2 Sept 14 Molecular organization and classification of collagens: fibril-forming collagens. Type I collagen and connective tissue defects due to the improper assembly of type I collagen In the ER: scurvy and osteogenesis imperfecta. L3 Sept 19 Supramolecular assembly and cross-linking of type I collagen molecules. Dermatosparaxis disease L4 Sept 21 Connective tissue collagen defects: Ehlers-Danlos syndrome Basal laminae/basement membranes: network-forming type IV collagen L5 Sept 26 Role of basal laminae in epithelial morphogenesis: focus on collagen IV. Role of collagen IV in kidney filtration Type VII collagens and anchoring fibrils in the dermal-epidermal junction zone and epidermolysis bullosa FACIT collagens and epiphyseal dysplasia Minicollagens and jelly fish nematocysts
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2 Hay E (Ed) Cell Biol of Extracellular Matrix, 2 nd Ed. 1991, Fig. 12-5 The major differences between an epithelial cell and a mesenchymal cells Epithelial cells sit on a basal lamina Golgi complex usually in apical cytoplasm Free surface is specialized for dealing with the outside environment Lateral surface form numerous junctions between cells Polarized epithelial cell Mesenchymal cells reside in the ECM and may be motile The Golgi complex is usually at the leading edge In most cases, they do not have specialized cell junctions Spindle shaped mesenchymal cells
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3 Thiery et al. Nature Reviews Molecular Cell Biology 7, 131–142 (February 2006) The cycle of events during which epithelial cells are transformed into mesenchymal cells and vice versa EMT EMT EMT MET MET MET Epithelial cells Mesenchymal cells Tight-junction dissociation Adherens junction & desmosome dissociation Tight junction formation, completion of cell polarity programme cortical actin cytoskeleton, reorganization, adherens-junction assembly Initial E-cadherin adhesive contact
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4 Hay E (Ed) Cell Biol of Extracellular Matrix, 2 nd Ed. 1991, Fig. 12-10 Epithelial to mesenchyme transformation (EMT) and vice versa The basal lamina has been dissolved by matrix metalloproteinases where the new mesenchymal cells are emigrating e.g. neural crest cell migration EMT
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