Chapter 5 - The Integumentary System

Chapter 5 - The Integumentary System - Chapter 5 The...

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Chapter 5 - The Integumentary System 13-Nov-16 5:14 PM Make certain that you can define, and use in context, each of the terms listed below, and that you understand the significance of each of the concepts. 1 Describe the anatomy and major functions of the skin. 1 integumentary system: regulates body temperature; stores blood; portects body from external environment; detects cutaneous sensations; absorbs and excretes substances; synthesizes vit D 2 skin or cutaneous membrane: covers ext surface; largest organ of body in weight 3 Epidermis: epithelial tissue; thinner layer 4 Dermis: connective tissue; vascular 5 subcutaneous (SQ) layer or hypodermis: Areolar and adipose tissue; deeper than dermis; serves as fat storage and contains blood vessel 6 lamellated corpuscle or pacinian corpuscle : dermis or subQ layer contains pressure receptors 7 Epidermis: composed of kerantinized stratified squamous epithelium 1 Keratinocyte: 90% of epidermal cells; produce keratin ; 4/5 layers; produce lamellar granules, that release water-repellent sealant that decreases water entry/loss 2 Keratin: tough, fibrous protein that protects skin 3 Melanocyte: 8%; produce melanin; have long projections; transfer melanin to keranocytes, forming protective layer over nucleus; melanocytes themselves are succeptible to UV becasuse they move their melanin away 1 Melanin:yellow/red or brown black pigment that absorbs UV 2 intraepidermal macrophages or Langerhans cell: arise from bone marrow; immune cells; help other cells recognize invading microbes and attack 3 tactile epithelial cells or Merkel cell: lest numerous, in deepest layer of epidermis; 1 tactile disk or Merkel disk: detect touch sensations 2 thin and thick skin also read 5.3: thin skin: 4 layers 1 Thick skin: epidermis has 5 layers; where friction is greatest 2 layers or strata 1 stratum basale or stratum germinativum: deepest layer: composed of signle row of cuboidal or columnar keratinocytes; stems cells are located here 1 keratin intermediate filaments (tonofilaments): protects cells and binds them together by attachching to desmosomes; and to hemidesmosomes in the basement membrane 2 stratum spinosum: 8-10 rows of keratinocytes with bundles of keratin intermediate filaments; contains projections of melanocytes and intraepidermal macrophages 3 stratum granulosum: 3-5 rows of keranocytes; organelles are begginning to degrade; 1 Keratohyalin: converts keratin intermediate filaments into keratin 2 lamellar granules: release lipid-rich, water repellent secretion 2 stratum lucidum; only in thick skin (finger tips, palms, soles); 4-6 rows of clear, flat, dead keratinocytes with large amounts of keratin 3 stratum corneum: up to 50 rows of dead, flat keratinocytes that contain mostly keratin 1 Callus: thickening of stratum corneum 2 BSGLC: order
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2 Keratinization: as cells move from one layer to another, they accumulate more keratin. Eventually undergo apoptosis 1 Takes 4-6 weeks 2 Based on epidermal growth factor; cells more profound are more
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