Unformatted text preview: Some of the rats “were subcutaneously administered FR260010 seven days after the SPS. Thirty minutes after this administration, they were subjected to five inescapable scrambled electric footshocks in a chamber… Twenty-four hours after the conditioning session, the animals were again placed in the same chamber, this time without footshock”(308). The behaviors of individual rats were recorded and examined based on whether the rat froze or moved every 10 seconds. The tissues from the hippocampus, amygdala, and anterior cingulate cortex were compared between the SPS and control rats. Of these three tissues the amygdala had the greatest number of differentially expressed genes. The 5-HT receptor mRNA also had a significant increase in the amygdala. “Comparative microarray analysis using RNA from the brains of both SPS rats and unstressed controls showed that the expression time course of 31 genes corresponded to the behavioral changes of SPS rats…...
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- Spring '08
- Brodmann area 24, Anterior cingulate cortex