Micro paper - Paper: Human Bocavirus and Simultaneous...

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Paper: Human Bocavirus and Simultaneous Respiratory Tract Infections in Children April 3, 2008 Respiratory tract infections are one of the most prevalent causes of death worldwide. However, one third of these cases cause mortality from an unidentified virus exhibiting an underlying co-infection, now identified as the human bocavirus (HBoV). It resembles the bovine parvovirus and the canine minute virus. It was isolated from the lower respiratory tract and was found to be prevalent mainly among children. Paroviruses commonly infect proliferating cells, which often results in systemic infection and symptomatic persistence. Koch’s postulates for human bocavirus have not yet been completely fulfilled, requiring additional study regarding the correlation between human bocavirus and simultaneous incidence of other respiratory infections. Also, the relatively novel discovery of the human bocavirus limits detailed study of the virus. Typical of children infected with HBoV are mild to moderate fevers. White blood cell count and protein levels are either normal or slightly augmented. Abnormalities are usually seen in the chest x-rays which showed hyperinflation and interstitial infiltrates (CDC). The main characteristic common to all HBoV infected patients was bronchiolitis. Other symptoms also exhibited, though to a lesser extent were dyspnea, respiratory distress, and cough. HBoV attacks children primarily under the age of 2. The percentage of children under the age of six months who are infected is very small; this indicates some resistance to maternal antibodies (Allander). Although females tended to be infected more so than males (61% to 39%, respectively), there was not correlation between sex and degree of virulence. Most children hospitalized due to HBoV were
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discharged within a week of hospitalization. The human bocavirus has been detected worldwide and prevalence rates have been determined to vary between 1.5-19%. Some of the reasons for the discrepancy may be due to the population studied and the sampling techniques employed (Allandar 1). No correlation with seasonality and the HBoV has been established. The samples taken for testing are derived from respiratory secretions and do not consider the presence of the virus without manifestation of physical symptoms. Also, most samples are submitted for testing coincidentally happen when respiratory infections are at a maximum. Whether or not there is a direct connection of HBoV and the seasons remains unknown. Similar cases of HBoV appear throughout the year.
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Micro paper - Paper: Human Bocavirus and Simultaneous...

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