D103 Lecture 12.2- actin - Bio D103 Cell Biology Instructor...

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Bio D103: Cell Biology Instructor: Dr. Scott Atwood Fall 2016
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Preclass quiz statistics
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After reading the paired chapters , you should be able to: Compare and contrast the elements that make up the cytoskeleton Describe how actin treadmilling occurs Describe how interaction between myosin and F-actin leads to muscle contraction Understand how actin binding proteins regulate actin filaments and cell motility After reviewing this lecture , you should be able to: Describe how actin influences stereocilia Describe how actin influences cell migration Understand how cells know where to migrate Lecture 12: Learning objectives
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Meet Connor and Dalton, they have Usher syndrome http://www.hearseehope.com/blog/conner-dalton-mckittrick-learning-live-usher-syndrome/
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Usher syndrome affects stereocilia, leading to deafness and blindness
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Cersei is interested in stereocilia formation as her children are more apt to acquire recessive genes. If actin makes up the rigid structure of stereocilia, how does the structure persist given the dynamic nature of actin filaments ? A. High monomeric actin concentration preferentially incorporates at the barbed end of the filament B. Actin treadmilling C. Filament severing D. Barbed end capping E. High nucleation rates iClicker question 12-1
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Cersei is interested in stereocilia formation as her children are more apt to acquire recessive genes. If actin
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