D103 Lecture 18.2- primary cilia

D103 Lecture 18.2- primary cilia - Bio D103 Cell Biology...

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Bio D103: Cell Biology Instructor: Dr. Scott Atwood Fall 2016
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Announcements Seating chart and seating assignments are posted on CANVAS under “files” we can accommodate left-hand seating - need to notify us We will provide a scantron and the exam 19 multiple choice questions covering lectures 10-18. You need to bring a number 2 pencil with an eraser and your student or government ID so we can verify who you are. Bags and backpacks will be brought to the front of the class No questions will be answered during the exam. Unclear questions will be looked at after the exam. There will be a 40 minute time limit If done early, turn your exam over and sit quietly. We will tell you when you can turn in your exam to a TA. Show your ID, and leave quietly through the doors. You will be allowed one 3 inch X 5 inch notecard for the exam
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Spindle-dependent and -independent cleavage formation
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Planar cell polarity in flies and mice A) bristles on fly wing, B) ommatidium of fly eye C) ependymal cells of mouse brain, D) mouse organ of Corti E) fly leg, F) mouse leg
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Planar cell polarity functional modules PCP signal: 3 functional modules: 1) core module: amplifies asymmetry and coordinates between cells Proximal : Flamingo (FMI)- cadherin, Van Gogh (VANG)- transmembrane protein, Prickle (PK)-scaffold Distal : Flamingo (FMI)- cadherin, Frizzled (FZ)- receptor, Disheveled (DSH) and Diego (DGO)- scaffolds 2) global module: converts tissue-level expression gradients to subcellular gradients Cadherins: Fat (FT) and Dachsous (DS) Golgi protein: Four-jointed (FJ)- makes FT stronger and DS weaker 3) Asymmetric core proteins - morphological polarity (variable)
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Planar cell polarity functional modules Shaking hands with the enemy: VANG-FMI complex preferentially interacts with a FZ-FMI complex between cells VANG-FMI complex preferentially suppresses a FZ-FMI complex within a cell Signaling: PK suppresses cortical F-actin DSH promotes Rho GTPase activation and cortical F-actin
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Planar cell polarity in hair follicle orientation B) developing mouse hairs E-cadherin expressed at all cell-cell contact regions
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