D103 Lecture 15.2- ECM - Bio D103 Cell Biology Instructor...

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Bio D103: Cell Biology Instructor: Dr. Scott Atwood Fall 2016
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Preclass quiz statistics
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After reading the paired chapters , you should be able to: Describe basement membranes and their functions Compare and contrast components of the ECM Understand how integrins connect the ECM to intracellular networks After reviewing this lecture , you should be able to: Understand how Vitamin C is important for the ECM Compare and contrast components of the ECM Describe how integrins and cadherins link the cytoskeleton to the outside of the cell Lecture 15: Learning objectives
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Meet Captain Jack. What disease would he likely have?
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iClicker question 15-1 Gendry was rescued from his rowboat by a group of sailors. Half the crew showed symptoms of scruvy. He hypothesized that something was missing from their diet. Which of the following remedies would help treat scruvy? A. gargled with 25 drops of sulfuric acid B. eat spice paste and drink barley water C. eat an orange and a lemon D. drink half a pint of seawater E. drink six spoonfuls of vinegar
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iClicker question 15-1 Gendry was rescued from his rowboat by a group of sailors. Half the crew showed symptoms of scruvy. He hypothesized that something was missing from their diet. Which of the following remedies would help treat scruvy? A. gargled with 25 drops of sulfuric acid B. eat spice paste and drink barley water C. eat an orange and a lemon D. drink half a pint of seawater E. drink six spoonfuls of vinegar
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Dr. Lind’s treatise on scurvy Modern scury: 3 studies at ASU showed ~3% of students have scurvy-levels of blood vitamin C Study by National Health and Nutrition reported 13 percent of US adult males and 9 percent of females have scurvy-levels of blood vitamin C Symptoms: develop ~3 months of severe vitamin C deficiency weakness and fatigue bruising and bleeding weakening of connective tissue and bones loss of hair and teeth
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Ascorbic acid is necessary for collagen maturation ER: procollagen, precursor of collagen, is synthesized prolyl and lysyl hydroxylase uses ascorbic acid to hydroxylate proline and lysine residues triple helix is formed N-linked glycosylation occurs Golgi: glycosylation modifications Secretion: N- and C-terminal non-
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