D103 Lecture 13.2- microtubules - Bio D103 Cell Biology...

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Bio D103: Cell Biology Instructor: Dr. Scott Atwood Fall 2016
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Preclass quiz statistics
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After reading the paired chapters , you should be able to: Describe how microtubules are assembled and disassembled Compare and contrast kinesins and dyneins Understand the function of MTOCs After reviewing this lecture , you should be able to: Describe how virus travel within cells Understand how perturbation of the cell would influence viral infection Describe how dynamic instability occurs Lecture 13: Learning objectives
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Meet Herpes Simplex, a disease cause by a virus
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Virus infection mechanisms Latency: Virus infects cell Capsid and genetic material travels to nucleus Infection is dormant until reactivated Reactivation: External signal initiates viral replication Virus particles are assembled Virus release via budding or lysis
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Tommen is interested how virus travel inside a cell. He suspects that _____ helps the capsid travel along microtubule tracks toward the nucleus, whereas _____ helps the capsid travel back towards the plasma membrane. A. Actin, Microtubules B. Kinesins, Dynein C. Dynein, Kinesins D. Myosins, Kinesins E. Dynein, Myosins iClicker question 13-1
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Tommen is interested how virus travel inside a cell. He suspects that _____ helps the capsid travel along microtubule tracks toward the nucleus, whereas _____ helps the capsid travel back towards the plasma membrane. A. Actin, Microtubules B. Kinesins, Dynein C. Dynein, Kinesins D. Myosins, Kinesins E. Dynein, Myosins iClicker question 13-1
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Dyneins and Kinesins transport capsids along MTs Dyneins are motor proteins that walk along MT filaments towards the minus end, whereas kinesins go towards the plus end
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Tommen wants to visualize viral entry into the cell. What
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